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Acute treatment of diet-induced obese mice with labelled semaglutide has been shown to allow the drug to access circumventricular organs that lack a substantial blood brain barrier, including the area postrema (AP), median eminence (ME), vascular organ of the lamina terminalis (OV), and subfornical organ (SFO) ( Figure 3 )

Anyone using Retatrutide alongside other glucose-lowering medications should discuss dose adjustments with their healthcare provider

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