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312 Lipotoxicity impairs insulin signaling, induces oxidative damage, promotes inflammation and fibrosis, 313 which is thought to be related to the progression of MAFLD patients from simple steatosis to NASH, hepatic fibrosis, and hepatocellular carcinoma

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Reeve JR Jr, Walsh JH, Chew P, Clark B, Hawke D, Shively JE

In summary, the activation of microglia and astrocytes, and the subsequent release of pro-inflammatory cytokines and ROS, create an unfavorable environment for neuronal damage and death