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doi: 10.1161/STR.0000000000000375

Retatrutide adds glucagon receptor agonism, which may further reduce visceral adiposity compared with GLP-1 single agonism, potentially amplifying androgenic benefit

Retetrutide is a peptide with a complex molecular structure, designed as a ligand for three types of G-protein coupled receptors (GPCRs): GLP-1 receptor (glucagon-like peptide-1 receptor) a receptor associated with insulinotropic signaling GIP receptor (glucose-dependent insulinotropic polypeptide receptor) a receptor involved in the response to glucose Glucagon receptor the receptor responsible for glucagon signaling In the classification of chemical compounds, retetrutide belongs to the group of synthetic peptides with a modified structure, designed to study multidirectional activation of receptors

Current Evidence and Regulatory Status in the UK Neither AOD 9604 nor retatrutide is licensed by the MHRA