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Further, the fact that the site of DA release is clearly localized to the associative striatum, overlaps with fMRI activity, and correlated with performance on the task, makes it unlikely that the conclusions we draw are driven by methodological confounds

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Payers are likely to have restrictive coverage criteria to restrict initial access to patients with highest clinical need, including BMI greater than 35 kg/m, multiple obesity-related comorbidities, and poor response to GLP-1 monotherapy