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During metastasis, a tiny fraction of tumor cells splits away from the primary tumor region enters the circulation (intravasation) and exits (extravasation) to form a secondary tumor at a distant region (Fig

During the lipid peroxidation pathway, ACSL4 promotes ferroptosis by producing oxidized PE at the endoplasmic reticulum (ER)-associated oxygenation center, and ACSL4 catalyzes the attachment of AA or adrenaline (AdA) to produce AA or AdA acyl Co-A derivatives, which is then esterified to PE (AA-PE and AdA-PE) by lysophosphatidylcholine acyltransferase 3 (LPCAT3)

So, current efforts are aimed to enhance its bioavailability by the application of nanotechnology

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