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Certain genetic mutations, particularly those affecting the X chromosome, can be an underlying cause of premature ovarian insufficiency (also known as primary ovarian insufficiency), a condition in which menstrual cycles become irregular or cease and FSH levels are persistently high before the age of 40 years

And Dr Aiken is right that there's no reason to neglect methylfolate in the context of some autisms, particularly where 'issues' with a certain gene - MTHFR - may also be present

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