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For example, a small number of subjects reported the following mild side effects in the course of a four-week glutathione study at the dose of 1g/day [13]: Flatulence Loose stools Flushing Weight gain In a more specialized study involving cystic fibrosis patients and much higher glutathione doses, some of the patients reported tightness in the torso, diarrhea, and fever-like symptoms [14]

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However, the low delivery efficiency caused by the stratum corneum barrier limits the therapeutic impact

Copper deficiency impairs mitochondrial biogenesis (PGC-1) and disrupts COX assembly (via COX17, SCO1, and SCO2), resulting in bioenergetic failure due to ATP deficiency