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TrRosseta was used for the 3D modeling of our fusion constructs, and structure validation was performed using the Ramachandran plot, ProSA-web, and ERRAT tools to detect errors in the 3D modeled structures of the fusion constructs

However, our understanding of the function of GLP-1RAs is not complete, and further research, including long-term and large clinical trials are warranted to properly evaluate the causal relationship between GLP-1RAs and the development and progression of various cancers

The increase in cAMP levels in -cells is a consequence of GLP-1R activation in these cells, which in turn enhances the secretion of growth inhibitory hormone through signaling pathways such as PKA and Calcium/Calmodulin-dependent protein kinase (Brereton et al., 2015)

This risk can increase with improper nutrient intake