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TNF-, NF-B, IL-1b, AP-1, and Mitogen-activated protein kinases (MAPKs) intermediates get activated after receiving the pro-inflammatory stimuli and release pro-inflammatory chemokines, MMPs, inflammatory enzymes, adhesion molecules, and angiogenic factors resulting in neo-vascularization, arthritic joint destruction and chronic inflammation

These neurons convey information on the LD cycle to the SCN, to regions that regulate pupillary responses as well as to sleep and waking systems 39

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