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Research protocols employ diverse approaches including isolated mitochondria preparations, permeabilized muscle fiber respirometry, stable isotope tracers for metabolic flux analysis, cellular bioenergetics assays (Seahorse), and in vivo metabolic phenotyping in rodent models

These results support further evaluation in chronic dosing paradigms, inclusion of both sexes, and pharmacokineticpharmacodynamic studies to optimize translation

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Clinical Toxicology 2006