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Several years of clinical research followed, with the lizard-derived exenatide becoming the first GLP-1 based medication approved for treating type 2 diabetes in 2005

Patients should understand that expected weight loss varies by medication (approximately 5-10% with liraglutide, 10-15% with semaglutide, and potentially higher with tirzepatide), though responses in post-bariatric patients may differ from those in primary obesity treatment

Roughly 2030% of patients are non-responders, but for the majority meaningful weight loss does occur