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Mutations in SOD1 can cause familial ALS (several pieces of evidence also show that wild-type SOD1, under conditions of cellular stress, is implicated in a significant fraction of sporadic ALS cases, which represent 90% of ALS patients.), [58] by a mechanism that is presently not understood, but not due to loss of enzymatic activity or a decrease in the conformational stability of the SOD1 protein

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Allergic responses involving hives, swelling, or difficulty breathing require immediate medical attention

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Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease

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