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A more satisfactory approach to the detection and management of malaria patients with G6PD deficiency would unlock a much broader anti-malarial armamentarium

After the binding of a new ATP molecule in the NBD, the client protein leaves the substrate binding pocket (Qi et al., 2013)

The function of APT2 emerges from the integration of its enzymatic activity, specific localization, and substrate selection, thereby regulating the balance among cell survival, apoptosis, pyroptosis, and ferroptosis