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Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core

GLP-1 (glucagon-like peptide-1) is an incretin hormone that stimulates insulin secretion, slows gastric emptying, and reduces appetite

Any references to metabolic, endocrine, or appetite-related pathways are provided strictly for scientific context within laboratory research and do not imply therapeutic, diagnostic, or clinical use

Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea