Increases of GTP (2.4-fold in plasma), uridine, and xanthine (2.8- and 4.0-fold in blood, respectively) were also prominent (Table 1)
It is also possible that the patient obtained a diagnosis after being dispensed the drug, or before the 5 years included for preexisting diagnoses in this study design
Signs & Symptoms Fatigue, weakness Swelling (edema) in legs, face Decreased urine output (oliguria/anuria) or sometimes polyuria in early CKD Nausea, vomiting, anorexia Shortness of breath (due to fluid overload) Confusion (from uremia) High blood pressure Itchy skin (uremic pruritus) Complications Electrolyte imbalance ( potassium arrhythmias) Metabolic acidosis Anemia ( erythropoietin) Bone disease (due to calcium-phosphate imbalance, vitamin D activation) Cardiovascular disease Management AKI: Treat underlying cause (e.g., fluids for dehydration, relieve obstruction, stop nephrotoxic drugs)
It also reduces the likelihood of nausea or flushing, which are dose-related effects
