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(1) Parameters measure size, not enlargement (2) Parameters are arbitrary and unsupported (3) CKCSs have normal hearts above VHS 10.5 value (4) Heart-healthy CKCS has a LA/Ao ratio way below 1.6 (5) All Stage B2 sub-groups are lumped together (6) Recommended parameters ignored study's data (7) Study glosses over pimo causing sudden deaths (8) Report hides categories of pimo-caused adverse events (9) Early termination leads to risk of false positives (10) Study ignores contractility and systolic functions (11) Report excludes data of pimo shortening life spans in CHF (12) Report provides no breed-specific information (13) Authors try to defend manufacturer's control over them (14) Report contradicts earlier, misleading press releases But what is most disturbing is what is not in the EPIC Study report

A major limitation of many of the studies investigating adjuvant treatment for HS is indirect assessment of the efficacy of the molecule under investigation