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Rosanoff, Weaver and Rude, 2012 Gaby's (2002) foundational paper on the Myers' Cocktail established its clinical utility across a range of conditions linked to nutritional deficiency and in the longevity context, its role is as the essential substrate layer of any serious anti-ageing IV protocol

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As a result, increased stiffness triggers the translocation of the transcription factor co-activators Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) to the nucleus where they interact with the transcriptional enhanced associate domain (TEAD) family of transcription factors to induce gene expression [85]