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Severe abdominal pain Abdominal distension

Gastrointestinal Effects Nausea affects approximately 28-31% of women at the 12mg dose, with higher rates during dose escalation periods

Abstract Despite an ever-growing prevalence and increasing economic burden of Alzheimers disease (AD) and Parkinsons disease (PD), recent advances in drug development have only resulted in minimally effective treatment

During the shortage, clinicians are also required to: Only prescribe GLP-1 RAs for their licensed indication Review the need for prescribing a GLP-1 RA agent and stop treatment if no longer required due to not achieving desired clinical effect as per NICE CG28 Avoid switching between brands of GLP-1 RAs, including between injectable and oral forms Where a higher dose preparation of GLP-1 RA is not available, do not substitute by doubling up a lower dose preparation Where GLP-1 RA therapy is not available, proactively identify patients established on the affected preparation and consider prioritising for review based on the criteria below