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1a and Supplementary Table 3) was extracted and the RNA assay was normalized using the SCTransform function with the percentage of mitochondrial reads regressing out in a second non-regularized linear, followed by the standard processing pipeline including principal component analysis, UMAP calculation, nearest neighbour discovery and cluster determination

Gallstones can develop when there is an imbalance in the substances that make up bile, such as cholesterol and bilirubin, or when the gallbladder does not empty properly

Approval was supported by the OASIS 4 phase 3 clinical trial, which followed 307 participants without diabetes for 64 weeks