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These tumors carry a dismal prognosis, with a pooled local recurrence rate of 42%, distant metastasis rate of 27%, and mortality rate of 26%

Traditionally, the understanding of MDR has long been confined to the drug efflux pump model, simplifying it as a passive defense mechanism, represented by the overexpression of ABC transporters, aimed at reducing intracellular drug concentration [1]

Once you're able, though, a combination of strength training and cardio exercises can help you not only lose weight, but also increase your strength, improve your energy levels and support your mental health, according to the Mayo Clinic

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