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These reactions require immediate medical attention

Moreover, genome-wide association studies (GWAS) across different ethnic groups have identified polymorphisms in over 70 non-HLA loci, some of which include key protein-encoding genes that have been shown to play an immune-associated function ( Figure 1 ) (56, 67, 68)

Buie T, Campbell DB, Fuchs GJ 3rd, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter H