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NGM282 for treatment of patients with primary biliary cholangitis: A multicenter, randomized, double-blind, placebo-controlled trial

Member of the Latinoamerican Board of Eli Lilly and Sanofi Aventis Member of the National Board of the following laboratories: Novo Nordisk, Novartis, GlaxoSmithKlein Sanofi, Aventis, Boheringer Ingelheim, Bristol Myers, Astra Zeneca Main investigator of Protocols from: Eli Lilly, Novo Nordisk, Novartis, GlaxoSmithKlein, Takeda, PPDF, Pfizer, Merck Sharp Dome, Amgen, Roche, Minimed, Quintiles Speakers of the former laboratories

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In terms of pharmacological properties, DON and BPTES show moderate potency, poor metabolic stability, low water solubility, and limited selectivity for GLS, resulting in inferior antitumor efficacy compared to CB-839 (246, 247)