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THE LANDMARK TRIAL PENN STATE, 6 MONTHS, PEER-REVIEWED: A 6-month randomized, double-blind, placebo-controlled human trial of 54 adults at Penn State University (Richie et al., European Journal of Nutrition, 2015) found that oral Setria L-Glutathione at 250 mg/day produced significant increases in whole-blood glutathione levels at 1, 3, and 6 months versus baseline establishing for the first time that oral glutathione is bioavailable in humans

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These findings are subject to important limitations including confounding by indication, concurrent medication use, and selection bias

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