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As mentioned before, Pycnogenol was shown to have potent anti-inflammatory activities in several studies (1518)

Repeated same-site injection is the most common self-inflicted cause of the injection-site irritation covered in the side-effects section below

These inflammatory responses not only impair testicular tissue, but also directly affect key cells involved in spermatogenesis, including spermatogonia, primary spermatocytes, and Sertoli cells, thereby exacerbating spermatogenesis disorders and leading to reduced sperm count and quality [67, 277]

Her practitioner advised a temporary reduction in dosage, and also changed the type of antimicrobials she was taking as she had an issue with Histamine