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The Genetic Switch: Understanding Nrf2 Activation If glutathione is conceptualized as the primary fuel of the cellular antioxidant system, a crucial question concerns the regulatory engine that governs its synthesis and utilization

10.1016/j.jhep.2015.03.039 141 TaflinskiL.DemirE.KauczokJ.FuchsP

The protective mechanisms involve activation of the Sirt1/Nrf2 pathway, preservation of mitochondrial function, and modulation of cell death pathways [194]

On the other hand, NAC shows stronger reactivity towards hypochlorite and nitrogen dioxide, partially explaining its direct antioxidant effects against exogenous factors like diet, air pollution, or certain inflammatory conditions (Meyer et al., 1994