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Potential risks include breast tenderness, headaches, slight increase in breast cancer risk with prolonged synthetic progestin use (not seen with micronized progesterone), blood clot risk with oral estrogen (not transdermal), and gallbladder disease risk with oral estrogen

Biochem Pharmacol 2015;93:40917

This results in an open cylindrical microchannel integrated within the 3D scaffold where the ECs are seeded and grown until a completely endothelialized circular lumen is achieved [259]