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Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of CSIC (protocol code 115/2017) and the Ethics Committee of Hospital Universitario Puerta de Hierro-Majadahonda (code 156-17, Acta 08.18)

While studies (50,73,74,151,82) have reported ChaC1/ChaC2 as tumor biomarkers, the development of ChaC1/ChaC2 tracer fluorescent probes remains unexplored

A: Activates GLP-1 receptors in the pancreas (glucose-dependent insulin secretion), hypothalamus (appetite regulation), and GI tract (delayed gastric emptying)

Changes in cortisol can interfere with the regular pulsatile release of gonadotropin-releasing hormone (GnRH), disrupting the normal menstrual cycle