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In RA, synovial macrophages are considered an important cell population driving chronic inflammation and joint destruction, and their metabolic reprogramming is closely associated with inflammatory phenotypes

Reconstituted IGF-1 LR3 should not be subjected to any freeze-thaw cycles in a multi-dose format

Despite the promising findings reported in preclinical studies, it is important to emphasize that the majority of the available evidence originates from animal models and cell culture experiments