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However, GLP-1 RA therapy has gastrointestinal side effects, including nausea, increases the risk of undernutrition, and can decrease lean body mass

Here is a simple breakdown based on the 6-day half-life: After 6 days, 50% of the dose remains After 12 days, 25% remains After 18 days, 12.5% remains After 24 days, about 6% remains After 30 days, less than 4% remains In practice, most pharmacologists consider a drug effectively cleared after 5 half-lives

The dosage can be increased gradually by the doctor to reach a maintenance dose of either 850 or 1,000 milligrams taken twice daily

Supplied as a lyophilised 20mg blend, 99% purity by HPLC, Certificate of Analysis on request