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Progressive thyroid cell damage can change the apparent clinical picture from goitrous hypothyroidism to that of primary hypothyroidism, or "atrophic" thyroiditis

Doxorubicin was selected as a training compound for three reasons: i) the quinone moiety, present in doxorubicin, is acknowledged as a notorious redox cycler

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FIGURE 1 Oxidative Stress and Inflammation as Prominent Mechanisms Involved in Diabetes-Induced Complications Several pathophysiological mechanisms have been implicated in the aggravation of diabetes-related complications