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To improve the pharmacological properties and enable tumor-selectivity, the phenylazopyridine ligand was terminally functionalized with a hydroxy group that could be used for further chemical modifications

PLoS ONE 10:e126599 Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M (2010) The selective autophagy substrate p62 activates the stress responsive transcription factor nrf2 through inactivation of keap1

others require patience as effects accumulate

However, its formulation and regulatory status are less established than Aqualyx, so practitioners should exercise caution and apply rigorous clinical judgement when incorporating it into practice