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The most commonly reported side effects include nausea, vomiting, diarrhea, and constipation, particularly when starting the medication or increasing the dose

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A rapid review of 25 studies similarly found that liraglutide and semaglutide reduced binge eating episodes and prevalence, with food cravings improving with semaglutide in 6 of 7 studies ( Jebeile et al., Obesity Reviews, 2026 )

Preclinical studies have demonstrated beneficial effects of proteasome activation in models of heart failure and ischemiareperfusion injury, 69 further supporting ER proteostasis as a therapeutically actionable axis