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Although its efficacy is lower than methotrexate and cyclosporine, apremilasts favorable safety profile, particularly its low hepatotoxicity risk, makes it a valuable option for patients who require long-term systemic therapy and cannot tolerate immunosuppressants (Papp et al

There are no randomized controlled trials defending that, nor is there any level of concrete data, Dr

88,94 These micoglial states have been termed M1 and M2 phenotypes (adapted from T-helper cell 1 and 2), although these 2 polarized states are too constricting in relation to micoglia, as they have the plasticity to heterogeniously change phenotype to optimize function in response to an almost endless variety of envioronmental challenges