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153 (3), e202012604

The three compounds intersect at cellular energy metabolism: NAD+ as a core coenzyme, MOTS-c as a mitochondrial signaling peptide, and 5-Amino-1MQ as an enzyme inhibitor affecting NAD+ availability

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GSH (-glutamyl-cysteinyl-glycine) is produced in two sequential enzymatic ATP-dependent reactions which occur exclusively in cytosol