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Pernicious anaemia occurs when the immune system attacks the healthy, specialised cells of the stomach that produce the intrinsic factor

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At the regulatory level, aberrant activation of canonical pro-inflammatory pathways such as NF-B disrupts junctional complexes and induces cytokines, including IL-1, thereby amplifying inflammation and further compromising barrier integritya self-perpetuating cycle (Zeng et al., 2024)