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The regulatory features of BCAAs in macrophage polarization are mainly reflected in their role as an intersection node linking nutrient sensing-mTOR signaling-energy metabolic coupling. After entering cells, BCAAs can be converted by BCAT into branched-chain -keto acids, which are further catabolized by the BCKDH complex to generate products such as acetyl-CoA, succinyl-CoA, or propionyl-CoA, thereby connecting to the supply of TCA cycle intermediates and mitochondrial oxidative metabolism (62)