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Human clinical trials are limited, and optimal dosing, long-term safety, and comparative effectiveness with other therapies remain unclear

Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

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The analysis documented GHK-Cu's ability to stimulate growth factor production, enhance fibroblast migration and collagen synthesis, and promote blood vessel formation (angiogenesis) all critical steps in the healing process