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3.4 Chronic viral hepatitis (HBV and HCV) While HBV and HCV are primarily known as infectious diseases, their persistent presence induces profound metabolic reprogramming specifically within the host liver cells (hepatocytes), which contributes significantly to the risk of advanced liver disease and HCC (Wang and Zhang, 2023

Acute, but not chronic, exendin-4 treatment increases Fgf7 mRNA expression in the small intestine (Koehler et al., 2015)

This helps trapped toxins exit the body

By contrast, preclinical studies in a rat model suggest that chronic intermittent exposure to ethanol is associated with decreased ALLO levels in the hippocampus