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Potential benefits of AOD-9604: Targeted fat loss Improved body composition Minimal hormonal effects Low incidence of systemic side effects AOD-9604 is generally viewed as a body-composition peptide rather than a major weight-loss medication
Studies examining ovariectomized, hormone-primed female rats showed: Dramatic increases in solicitation behaviors (hopping, darting, ear-wiggling) at doses of 100-200 mcg/kg No effects on consummatory behaviors such as lordosis Selective enhancement of proceptive (desire-related) behaviors without affecting receptivity Effects mediated through the medial preoptic area, as direct mPOA injections replicated systemic effects These findings established PT-141 as the first pharmacological agent demonstrating selective appetitive sexual behavior enhancement in preclinical models
doi: 10.1038/icb.2008.62 5 KorneteMMasonESPiccirilloCA
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