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Eligible patients with DTC should not be denied the cardiometabolic benefits of GLP-1RA when clinically indicated

9:00 - ASSAY DEVELOPMENT FOR PYRUVATE DEHYDROGENASE KINASE INHIBITOR DISCOVERY Nathan Lilla University of Nebraska at Kearney Pyruvate dehydrogenase kinase (PDK) regulates the activity of the pyruvate dehydrogenase complex (PDC) by phosphorylating its E1 subunit, thereby limiting conversion of pyruvate to acetyl-CoA, restricting entry into the TCA cycle, and reducing ATP production

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Bicarbonate is exchanged for chloride from the blood on the basolateral side of the parietal cell and the Cl- ions are transported to the lumen of the stomach to form HCl