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Rapid-acting insulin analogues are also formulated as premixes, combining mixtures of the insulin with protamine suspension and the rapid-acting insulin

Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, et al

Brain insulin resistance may indeed play a role in the pathophysiology of cognitive disorders, and addressing this may be a mechanism through which GLP-1RAs act pro-cognitively 35