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Characterizing dual GLP-1/GIP receptor agonists demands tools that resolve receptor engagement with specificity and spatial resolution that conventional approaches cannot provide

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Similarly, in LDL receptor knock-out mice subjected to a Western diet, treatment-reduced plaque lesions and semaglutide were reported to affect the expression of several genes related to cholesterol metabolism, leukocyte recruitment, adhesion and extravasation, and also extracellular matrix protein turnover [35]