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Interestingly, silica particles serve a dual purpose: acting as a substrate for a robust murine pulmonary fibrosis model characterized by sustained fibrotic lesions and functioning as a potent activator of the NLRP3 inflammasome [28]

For example, miR-483-5p and miR-503-5p have been proposed as candidate markers for SAP-associated ALI, 537 whereas miR-21-5p is reportedly elevated in the serum EVs of patients with type 1 autoimmune pancreatitis and can help distinguish CP patients from healthy individuals

To conclude, peptide-based therapies can promote immune tolerance and have shown great potential in reducing disease activity in lupus patients

Looking ahead, the introduction of generic drugs may present specific challenges, making the accurate identification of impurities and assurance that they remain below safe levels critically important