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For example, a combinatorial pretreatment with an antioxidant, a p53 inhibitor, and a neurotrophin provided significant multifactorial protection against cisplatin-induced ototoxicity in vitro and in cochlear explants, addressing concurrent biological mechanisms of cell death (Febles et al., 2022)

3 Stick on Place the patch on clean, dry skin in a comfortable area

Subsequently, ATF4 binds to the amino acid response element (AARE) of gene promoter to further promote the transcription of genes involved in amino acid metabolism and stress response, such as SLC7A11, so that cells can cope with amino acid constraints (Kilberg et al., 2009)

(PubMed) Wahlin A, Hill RD, Winblad B, Backman L