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Defining the interaction between dopamine with this coreceptor is particularly important because dopamine could interfere with the effectiveness of antiretroviral drugs like maraviroc, which target CCR5 (Matt et al., 2021)

[DOI] [PubMed] [Google Scholar] Flierl MA, Rittirsch D, Nadeau BA, Sarma JV, Day DE, Lentsch AB, Huber-Lang MS, Ward PA (2009) Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response

Because the unusual bond formed through the gamma-carboxyl group of glutamate can only be hydrolyzed by one enzyme, gamma-glutamyltranspeptidase, which is present only on the external surfaces of certain cells

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