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An Abbreviated New Drug Application (ANDA) for a generic nasal spray must demonstrate that the generic product is bioequivalent to the Reference Listed Drug (RLD)

many patients begin with a short series of injections spaced over weeks, then shift to a maintenance schedule that holds the gains

In obesity, the spontaneous (197, 198) and stimulated (199) pulsatile patterns of GH secretion governed by the hypothalamus are blunted, and the accumulation of abdominal adiposity, particularly visceral adipose tissue mass, was found to be a stronger negative determinant of GH secretion than other factors including age, sex, or generalized obesity (200202)