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How to Reduce Side Effects Most of what helps is simple: Smaller, more frequent meals instead of large portions Protein at the start of each meal, for both energy and satiety Consistent hydration, not just when you remember Avoiding high-fat or heavily processed foods early in treatment A gradual dose escalation rather than pushing the dose If reflux is part of what you're dealing with, does semaglutide cause acid reflux has more on managing it