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These indicated that Clopidogrel induced ER stress not only promotes the gastric mucosal cells apoptosis but also reduce the release of eNOS -mediated NO products

Oxidative stress plays an essential and complex role throughout its occurrence and progression [2,3,4,5,6], to which reactive oxygen species (ROS) are the primary contributors

GSH/system Xc-/GPX4 pathway GSH is a tripeptide composed of three amino acids (cysteine, glutamate, and glycine) and is one of the most abundant antioxidants in cells [63]

Although peroxynitrite is relatively stable compared to other free radicals, once protonated, it forms highly reactive peroxynitrous acid (ONOOH)