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Corrado advises working with an experienced provider on dose adjustments: While clinical trials often increase doses every four weeks to the maximum, many real-world patients achieve meaningful results with slower adjustments and without ever reaching the highest dose. Talk to your doctor about whether these medications make sense for you

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[11] [12] They may be considered earlier in people with a BMI 35 kg/m (adjusted for ethnicity) or for whom weight loss would benefit other obesity-related comorbidities

Current data does not establish a definitive causal link between GLP-1 medications and bone loss , but several studies have examined potential associations