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The on-target indel efficiency at the Alb locus was 20.2% in the Donor+Cas9-treated group (Supplementary Fig

The possible involvement of sensory neurons in the salutary effects of NaBPC157 (10 g/kg, 10 ng/kg i.p.) was studied with capsaicin which has quite distinct effects on sensory neurons: high dose administration to adult animals (125 mg/kg s.c., (subcutaneously) three months of age) or administration (50 mg/kg s.c.) to neonatal animals (seven days of age) destroys sensory fibers, whereas a low dose (500 g/kg i.p.) activates a neurotransmitter release and protective effects on the mucosa